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KMID : 0352519920290010137
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Korea Univercity Medical Journal
1992 Volume.29 No. 1 p.137 ~ p.150
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Thyroid Stimulating Hormone, Prolactin and Growth Hormone Responses After Thyrotropin-Releasing Hormone Administration in Major Depression and Schizophrenic Patients
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Abstract
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The effects of thyrotropin-releasing hormone(TRH) on the release of thyroid stimulating hormone(TSH), prolactin(PRL) and growth hormone(GH) were investigated in 19 major depression patients. twenty-three schizophrenic patients and 20 normal
controls.
Basal TSH levels of major depression patients were significantly lower than those of schizophrenic patients(p<0.05). and basal PRL levels of major depression patients were significantly higher than thore of normal. controls(p<0.01). But basal GH
levels
were not significantly different among three groups. Total thyroxine (T4) levels of schizophrenic patients were significantly higher than those of major depression patients and normal controls(p<0.05, p<0.05). And free T: indexes of schizophrenic
patients were significantly higher than those of major depression patients and normal controls(p<0.01. P<0.05). But the levels of triiodothyronine(T) uptake and cortisol were not significantly different among three groups. The peak of TSH level
after
TRH administration in major depression patients was significantly lower than that of normal controls(p<0.01). The peak of PRL level in major depression patients was higher than those of schizophrenic patients and normal controls(p<0.05. p<0.01).
And the
peak of GH level in schizophrenic patients was significantly higher than that of normal controls(p<0.05). Most peaks of TSH and PRL level occurred almost about 30 minutes and 15 minutes after TRH administration.
Sixty-three percent of major depression patients showed blunted TSH response to TRH stimulation test. compared to 13% of schizophrenic patients. and 10% of normal controls. Major depression patients had significantly higher rate of blunted TSH
response
to TRH stimulation test than schizophrenic patients and normal controls(p<0.01, p<0.01). Forty-eight percent of schizophrenic patients showed blunted PRL response to TRH stimulation test. compared to 5% of major depression patients and no
response
of
normal controls. Schizophrenic patients had significantly higher rate of blunted PRL response to TRH stimulation test than major depression patients and normal controls(p<0.05, p<0.01). forty-seven percent of major depression patients and 57% of
schizophrenic patients showed the abnormal GH response to TRH stimulation test compared to 5% of normal controls. These changes underscore that major depression and schizophrenic patients had significantly higher rates of the abnormal GH response
to TRH
stimulation test than normal controls(p<0.05, p<0.05).
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KEYWORD
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